Figure 3. Heat map of unsupervised clustering (genes only) of 296 genes selected for both high variance (from a set of 500 most variant genes) and also as representative of six major patterns of distinctly correlated genes across the dataset.

These patterns included an Immune Response signature (up- or down-regulated between controls and disease: IR-UR and IR-DR, respectively), the Erythroid Differentiation Signature (EDS) a Platelet specific signature (Pl), and an Immature Neutrophil Signature (INS). The gender specific cluster acts as a positive control, the specific signatures are discussed in detail in the text, particularly that of the EDS.