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Cold temperatures or β3-adrenergic stimulations induce miR-196a in the WAT-resident progenitor cells in mice. miR-196a post-transcriptionally suppress Hoxc8, which is one of the white-fat genes. The direct target of Hoxc8 is C/EBPβ, a master switch of brown adipogenesis that provokes brown fat gene program in the WAT-progenitor cells.
