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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Mol Neurosci. 2011 Dec 23;47(1):139–143. doi: 10.1007/s12031-011-9696-y

Figure.

Figure

Pathological findings in three LRRK2 G2019S mutation carriers with PD.

Panel A–C [Luxol Haematoxylin Eosin (LHE) stain] shows Lewy Bodies (LB)s in the substantia nigra pars compacta (SNpc) (magnification 400x).

Panel D–F (alpha-synuclein stain) depicts alpha-synuclein reactive LBs and Lewy neurites (LNs) in the SNpc (magnification 400x).

Panel G–I (LHE stain) reveals LBs in the locus coeruleus (LC) (magnification 630x).

Panel J, K (substantia Innominata) and L (motor cortex) shows LBs and LNs reactive to alpha-synuclein stain (magnification 200x).

Picture M (LHE stain) shows a single NFT in the hippocampal formation cornus Ammonis 1 (CA1). Panel N and O (Bielschowsky) reveals NFTs and ghost tangles in CA1.

Panel P–R (AT8 stain) demonstrates tau-immunoreactive NFTs (magnification 200x).