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Mechanisms regulating PI3K pathway in melanoma. PI3K is one of the key proteins involved in the development of melanoma. PI3K expression and activities are regulated by mutational activation, elevated protein expression and loss of negative regulators such as PTEN. Activated PI3K converts PIP2s in to PIP3s, which in turn binds to plextrin homology domains of various kinases such as Akt thereby helps in the translocation of these proteins to cell membranes.
