Figure 3.

IDO deficiency accentuates hyperlipidemia in a mouse model of atherosclerosis driven by high fat diet. Blood serum samples were analyzed from WT, LDLR-/- or IDO-/-LDLR-/- mice on the C57BL6/J strain background. A representative illustration of hyperlipidemia present in mice fed a high fat diet is shown. Quantification of serum lipids demonstrated a significant increase in serum triglycerides in IDO-/-LDLR-/- mice fed an atherogenic diet (p < 0.02). No significant differences in levels of serum cholesterol were observed. Total mice tested in each group was IDO-/- (n = 10), IDO-/-LDLR-/- (n = 10), LDLR-/- (n = 9).