Table 1.
Methylation only hypermethylated gene probes
| Sporadic Rccs | ||||||
| Selected Probes | Symbol | Target Id | Meth + (B ≥ 0.5 Or Diff ≥ 0.4) | Normal Kidneys | Chr | Product |
| 1 | FOXL1 | cg06995715 | 14/38 (36.8%) | 0/9 | 16 | forkhead box L1 |
| 2 | TM6SF1 | cg14696396 | 13/38 (34.2%) | 0/9 | 15 | transmembrane 6 superfamily member 1 |
| 3 | SLC34A2 | cg19616230 | 13/38 (34.2%) | 0/94 | 4 | solute carrier family 34 (sodium phosphate); member 2 |
| 4 | SOCS2 | cg04797323 | 12/38 (32.6%) | 0/9 | 12 | suppressor of cytokine signaling-2 |
| 5 | TNFRSF10C | cg27090216 | 12/38 (32.6%) | 0/9 | 8 | tumor necrosis factor receptor superfamily; member 10c precursor |
| 6 | OVOL1 | cg20909686 | 12/38 (32.6%) | 0/9 | 11 | OVO-like 1 binding protein |
| 7 | TRIM58 | cg07533148 | 12/38 (32.6%) | 0/9 | 1 | tripartite motif-containing 58 |
| 8 | TLX3 | cg25720804 | 12/38 (32.6%) | 0/9 | 5 | T-cell leukemia; homeobox 3 |
| 9 | UTF1 | cg09053680 | 12/38 (32.6%) | 0/9 | 10 | undifferentiated embryonic cell transcription factor 1 |
| 10 | POU4F2 | cg24199834 | 11/38 (28.9%) | 0/9 | 4 | POU domain; class 4; transcription factor 2 |
| 11 | NOTCH3 | cg06650786 | 11/38 (28.9%) | 0/9 | 19 | Notch homolog 3 |
| 12 | ZNF177 | cg09643544 | 11/38 (28.9%) | 0/9 | 19 | zinc finger protein 177 |
| 13 | C1orf104 | cg22234962 | 10/38 (26.3%) | 0/9 | 1 | hypothetical protein LOC284618 |
| 14 | ICAM4 | cg21494776 | 10/38 (26.3%) | 0/9 | 19 | intercellular adhesion molecule 4 isoform 1 precursor |
| 15 | ZNF454 | cg03355526 | 10/38 (26.3%) | 0/9 | 5 | zinc finger protein 454 |
| 16 | AEBP1 | cg02126753 | 10/38 (26.3%) | 0/9 | 7 | adipocyte enhancer binding protein 1 precursor |
| 17 | SCARF2 | cg14785479 | 10/38 (26.3%) | 0/9 | 22 | scavenger receptor class F; member 2 isoform 2 |
| 18 | PENK | cg04598121 | 10/38 (26.3%) | 0/9 | 8 | proenkephalin |
| 19 | HCG9 | cg04623837 | 9/38 (23.7%) | 0/9 | 6 | hypothetical protein LOC10255 |
| 20 | PRAC | cg12374721 | 9/38 (23.7%) | 0/9 | 17 | small nuclear protein PRAC |
| 21 | GPC2 | cg18691434 | 9/38 (23.7%) | 0/9 | 7 | glypican 2 |
| 22 | COL1A2 | cg25300386 | 9/38 (23.7%) | 0/9 | 7 | α2 type I collagen |
| 23 | PRPH | cg09595479 | 9/38 (23.7%) | 0/9 | 12 | peripherin |
| 24 | ZNF154 | cg08668790 | 9/38 (23.7%) | 0/9 | 19 | zinc finger protein 154 (pHZ-92) |
| 25 | UNQ9433 | cg17162024 | 9/38 (23.7%) | 0/9 | 8 | hypothetical protein LOC389658 |
| 26 | IRX2 | cg15433631 | 9/38 (23.7%) | 0/9 | 5 | iroquois homeobox protein 2 |
| 27 | TMPRSS2 | cg24901042 | 8/38 (21.1%) | 0/9 | 21 | transmembrane protease; serine 2 |
| 28 | CDKN2B | cg10210238 | 8/38 (21.1%) | 0/9 | 9 | cyclin-dependent kinase inhibitor 2B isoform 2 |
| 29 | RAMP1 | cg03270167 | 8/38 (21.1%) | 0/9 | 2 | receptor activity-modifying protein 1 precursor |
| 30 | GSTP1 | cg04920951 | 8/38 (21.1%) | 0/9 | 11 | glutathione transferase |
| 31 | SLC15A3 | cg21992250 | 8/38 (21.1%) | 0/9 | 11 | solute carrier family 15; member 3 |
| 32 | FBN2 | cg25084878 | 8/38 (21.1%) | 0/9 | 5 | fibrillin 2 precursor |
| 33 | DLEC1 | cg23881725 | 8/38 (21.1%) | 0/9 | 3 | deleted in lung and esophageal cancer 1 isoform DLEC1-L1 |
| 34 | ZNF540 | cg03975694 | 8/38 (21.1%) | 0/9 | 19 | zinc finger protein 540 |
| 35 | IRX4 | cg03963198 | 8/38 (21.1%) | 0/9 | 5 | iroquois homeobox protein 4 |
| 36 | FLT4 | cg00489401 | 8/38 (21.1%) | 0/9 | 5 | fms-related tyrosine kinase 4 isoform 1 |
| 37 | ZNF154 | cg21790626 | 8/38 (21.1%) | 0/9 | 19 | zinc finger protein 154 (pHZ-92) |
| 38 | FBXO39 | cg20723355 | 8/38 (21.1%) | 0/9 | 17 | F-box protein 39 |
| 39 | RIMS4 | cg19332710 | 8/38 (21.1%) | 0/9 | 20 | regulating synaptic membrane exocytosis 4 |
| 40 | BCAN | cg21475402 | 7/38 (18.4%) | 0/9 | 1 | brevican isoform 2 |
| 41 | CA3 | cg18674980 | 7/38 (18.4%) | 0/9 | 8 | carbonic anhydrase III |
| 42 | SOCS2 | cg23412850 | 7/38 (18.4%) | 0/9 | 12 | suppressor of cytokine signaling-2 |
| 43 | OXR1 | cg17176732 | 7/38 (18.4%) | 0/9 | 8 | oxidation resistance 1 |
| 44 | CBX4 | cg04398978 | 7/38 (18.4%) | 0/9 | 17 | chromobox homolog 4 |
| 45 | ABCA3 | cg00949442 | 7/38 (18.4%) | 0/9 | 16 | ATP-binding cassette; sub-family A member 3 |
| 46 | DGKE | cg01344452 | 7/38 (18.4%) | 0/9 | 17 | diacylglycerol kinase epsilon |
| 47 | TNFRSF10C | cg14015044 | 7/38 (18.4%) | 0/9 | 8 | tumor necrosis factor receptor superfamily; member 10c precursor |
| 48 | SPAG6 | cg25802093 | 7/38 (18.4%) | 0/9 | 10 | sperm associated antigen 6 isoform 1 |
| 49 | COL1A2 | cg18511007 | 7/38 (18.4%) | 0/9 | 7 | α2 type I collagen |
| 50 | HTR7 | cg06291867 | 7/38 (18.4%) | 0/9 | 10 | 5-hydroxytryptamine receptor 7 isoform d |
| 51 | OVOL1 | cg13496736 | 7/38 (18.4%) | 0/9 | 11 | OVO-like 1 binding protein |
| 52 | HIST1H1A | cg10146929 | 7/38 (18.4%) | 0/9 | 6 | H1 histone family; member 1 |
| 53 | HLF | cg04219321 | 7/38 (18.4%) | 0/9 | 17 | hepatic leukemia factor |
| 54 | CCDC37 | cg00891278 | 7/38 (18.4%) | 0/9 | 3 | hypothetical protein LOC348807 |
| 55 | UQCRH | cg21576698 | 7/38 (18.4%) | 0/9 | 1 | ubiquinol-cytochrome c reductase hinge protein |
| 56 | TCFL5 | cg10729531 | 7/38 (18.4%) | 0/9 | 20 | transcription factor-like 5 protein |
| 57 | SALL3 | cg15191648 | 7/38 (18.4%) | 0/9 | 18 | sal-like 3 |
| 58 | CACNA1G | cg18454685 | 7/38 (18.4%) | 0/9 | 17 | voltage-dependent calcium channel α1G subunit isoform 1 |
| 59 | GRM6 | cg14859460 | 7/38 (18.4%) | 0/9 | 5 | glutamate receptor; metabotropic 6 precursor |
| 60 | CHD5 | cg08080029 | 7/38 (18.4%) | 0/9 | 1 | chromodomain helicase DNA binding protein 5 |