FIGURE 5. Methylphenidate treatment for eight days increases phosphorylation of Akt and reduces phosphorylation of GSK3 in the cerebral cortex.
A. Phospho-Thr308-Akt and phospho-Ser473-Akt were increased in the cerebral cortex after 20 mg/kg methylphenidate treatment for eight days. B. Phospho-Ser21-GSK3α and phospho-Ser9-GSK3β were increased in the cerebral cortex after methylphenidate treatment for eight days. Values are presented as percent of matched control mice. Means ± SEM. n=3. *, p≤0.05.