Table 2.

Molecules of importance in angiogenesis

Stimulatory	Inhibitory
VEGF/VEGFR	Angiostatin
FGF/FGFR	Endostatin
PDGF/PDGFR	Interferon α
PLGF	TP53
Ang1/Ang2	Thrombospondin
TNF-α, TGF-β	Tumstatin
Integrins
VE Cadherin/CD31
Ephrins
HIF-1α
IL-6, IL-8
Pleiotropin

Abbreviations: VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor 2; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; PLGF, placental growth factor; Ang, angiogenin; TGFα, transforming growth factor α; TGFβ, transforming growth factor β; HIF-1α, hypoxia-inducible factor 1α; IL, interleukin