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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Neurochem Int. 2011 Dec 17;61(4):601–609. doi: 10.1016/j.neuint.2011.11.016

Figure 3.

Figure 3

Concentration-response data for GluN2B-selective non-competitive antagonists at human and rat NMDA receptors. Determination of IC50 values ifenprodil, eliprodil, clobenpropit, and Ro 25–6981 at recombinant human (A) and rat (B) GluN1/GluN2B receptors expressed Xenopus oocytes was performed using two-electrode voltage-clamp electrophysiology. IC50 values are listed in Table 4. Antagonists were applied in the presence of 100 µM glutamate plus 30 µM glycine. (C) IC50 values for GluN2B-selective antagonists at human and rat NMDA receptor GluN1/GluN2B receptors were significantly correlated (Pearson test, P < 0.05, r = 0.99).