Table 2. Genes associated with alcoholism are differentially expressed.
Differentially expressed genes (FDR ≤ 15% and expression difference ≥ 10%) that have previously been associated with the risk for alcoholism (Bierut et al., 2010; Dick et al., 2008; Edenberg et al., 2010; Edenberg et al., 2006; Hill et al., 2004; Kalsi et al., 2009; Reich et al., 1998; Treutlein et al., 2009; Wang et al., 2009) are shown
| Transcript cluster ID | Gene | Gene Description | Fold-Change (E/C) | Differential expression FDR |
|---|---|---|---|---|
| 3521174 | ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 1.14 | 0.01 |
| 3606304 | AKAP13 | A kinase (PRKA) anchor protein 13 | 1.22 | 0.01 |
| 3927226 | APP | amyloid beta (A4) precursor protein | 1.13 | 0.00 |
| 3673684 | CDT1 | chromatin licensing and DNA replication factor 1 | −1.22 | 0.00 |
| 3603436 | CHRNA5 | cholinergic receptor, nicotinic, alpha 5 | 1.36 | 0.02 |
| 2772968 | COX18 | COX18 cytochrome c oxidase assembly homolog (S. cerevisiae) | −1.23 | 0.01 |
| 3720228 | CRKRS | Cdc2-related kinase, arginine/serine-rich | 1.19 | 0.02 |
| 3652424 | EEF2K | eukaryotic elongation factor-2 kinase | 1.11 | 0.01 |
| 3260383 | ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 1.12 | 0.01 |
| 2948587 | FLOT1 | flotillin 1 | −1.15 | 0.01 |
| 3199511 | FREM1 | FRAS1 related extracellular matrix 1 | 1.82 | 0.00 |
| 2469825 | GREB1 | GREB1 protein | 1.24 | 0.01 |
| 3636391 | HOMER2 | homer homolog 2 (Drosophila) | 1.27 | 0.01 |
| 3349660 | HTR3B | 5-hydroxytryptamine (serotonin) receptor 3B | 2.13 | 0.00 |
| 3779362 | IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | −1.24 | 0.01 |
| 3817733 | JMJD2B | jumonji domain containing 2B | −1.17 | 0.00 |
| 3517793 | KLF12 | Kruppel-like factor 12 | 1.30 | 0.00 |
| 2667809 | OSBPL10 | oxysterol binding protein-like 10 | 1.17 | 0.01 |
| 2698996 | PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 1.88 | 0.00 |
| 3358361 | PDDC1 | Parkinson disease 7 domain containing 1 | −1.16 | 0.02 |
| 2361401 | PMF1 | polyamine-modulated factor 1 | −1.19 | 0.02 |
| 2480168 | PRKCE | protein kinase C, epsilon | 1.20 | 0.00 |
| 3213847 | SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 1.31 | 0.02 |
| 2902884 | SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | −1.16 | 0.02 |
| 3369366 | SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 1.17 | 0.01 |
| 2610544 | SLC6A11 | solute carrier family 6 (neurotransmitter transporter, GABA), member 11 | 1.23 | 0.01 |
| 3751794 | SLC6A4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 1.20 | 0.00 |
| 3318666 | SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 1.18 | 0.03 |
| 2378662 | TRAF5 | TNF receptor-associated factor 5 | 1.84 | 0.00 |
| 3316375 | TSPAN4 | tetraspanin 4 | −1.20 | 0.00 |
| 3896976 | TXNDC13 | thioredoxin domain containing 13 | 1.23 | 0.00 |
| 3815328 | WDR18 | WD repeat domain 18 | −1.19 | 0.01 |
| 3989089 | ZBTB33 | zinc finger and BTB domain containing 33 | 1.27 | 0.01 |
| 3971923 | ZFX | zinc finger protein, X-linked | 1.16 | 0.00 |
| 3078478 | ZNF786 | zinc finger protein 786 | 1.20 | 0.03 |