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. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2012 Mar 18;260(3):285–293. doi: 10.1016/j.taap.2012.03.006

Fig. 3 — Impact of siRNA knockdown of CTR1 on the Mn-induced cellular Cu accumulation. (A) siRNA knockdown of CTR1decreased the CTR1 mRNA transcription. Data represent mean ± SE, n=6; **: p<0.01 as compared to NC (negative control or scramble siRNA). (B) CTR1 protein levels were decreased following the siRNA treatment. (C) CTR1siRNA knockdown decreased cellular ⁶⁴Cu uptake. Data represent mean ± SE, n=6; **: p<0.01 as compared to NC.

Fig. 3 — Impact of siRNA knockdown of CTR1 on the Mn-induced cellular Cu accumulation. (A) siRNA knockdown of CTR1decreased the CTR1 mRNA transcription. Data represent mean ± SE, n=6; **: p<0.01 as compared to NC (negative control or scramble siRNA). (B) CTR1 protein levels were decreased following the siRNA treatment. (C) CTR1siRNA knockdown decreased cellular ⁶⁴Cu uptake. Data represent mean ± SE, n=6; **: p<0.01 as compared to NC.