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. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2012 Mar 18;260(3):285–293. doi: 10.1016/j.taap.2012.03.006

Fig. 4 — Impacts of siRNA knockdown of DMT1 on the Mn-induced cellular Cu accumulation. (A) siRNA knockdown of DMT1 decreased the DMT1 mRNA transcription. Data represent mean ± SE, n=6; **: p<0.01 as compared to NC. (B) DMT1 protein levels were decreased following the siRNA treatment. (C) DMT1 siRNA knockdown failed to decrease the ⁶⁴Cu uptake, but instead increased the cellular Cu uptake, as compared to controls and NC. Data represent mean ± SE, n=6. *: p<0.05 compared to the NC.

Fig. 4 — Impacts of siRNA knockdown of DMT1 on the Mn-induced cellular Cu accumulation. (A) siRNA knockdown of DMT1 decreased the DMT1 mRNA transcription. Data represent mean ± SE, n=6; **: p<0.01 as compared to NC. (B) DMT1 protein levels were decreased following the siRNA treatment. (C) DMT1 siRNA knockdown failed to decrease the ⁶⁴Cu uptake, but instead increased the cellular Cu uptake, as compared to controls and NC. Data represent mean ± SE, n=6. *: p<0.05 compared to the NC.