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. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2012 Mar 18;260(3):285–293. doi: 10.1016/j.taap.2012.03.006

Fig. 6 — Induction of CTR1 in iZCTR1 cells at the steady state of Mn exposure and the cellular Cu accumulation. The iZCTR1 cells were exposed to 100 μM Mn for 24 h, followed by Tet treatment for 4 h. (A) Tet induced a drastic increase Cu uptake following Mn exposure in CTR1-inducible cells. (B) Tet induction increased CTR1 mRNA level in the Mn-treated iZCTR1 cells. Data represent mean ± SE, n=6; *: p<0.05 compared to controls; ##: p<0.01 compared to Mn-treated group. (C) Tet induction increased CTR1 protein levels in the Mn-treated iZCTR1 cells.

Fig. 6 — Induction of CTR1 in iZCTR1 cells at the steady state of Mn exposure and the cellular Cu accumulation. The iZCTR1 cells were exposed to 100 μM Mn for 24 h, followed by Tet treatment for 4 h. (A) Tet induced a drastic increase Cu uptake following Mn exposure in CTR1-inducible cells. (B) Tet induction increased CTR1 mRNA level in the Mn-treated iZCTR1 cells. Data represent mean ± SE, n=6; *: p<0.05 compared to controls; ##: p<0.01 compared to Mn-treated group. (C) Tet induction increased CTR1 protein levels in the Mn-treated iZCTR1 cells.