TABLE 5.
Associations of Haplotypes in IBD5, IL23R Genes and CD Risk
| Locus/Gene | Haplotype | Proportion in Cases | Proportion in Controls | OR (95% CI) | P-value |
|---|---|---|---|---|---|
| IBD5 (SLC22A4, SLC22A5, IGR2230, IGR2198, IGR2096) | |||||
| CGGCG | 0.437 | 0.554 | Reference | 0.001 (global) | |
| TCAGT | 0.466 | 0.372 | 1.62 (1.23–2.14) | 0.0006 | |
| CCACG | 0.048 | 0.030 | 2.12 (1.07–4.20) | 0.03 | |
| TCAGG | 0.019 | 0.008 | 3.09 (0.98–9.74) | 0.05 | |
| IL23R (rs1495965, rs10889677, rs11209026, rs2201841, rs7517847) | |||||
| ACGTT | 0.198 | 0.240 | Reference | 0.0001 (global) | |
| GAGCT | 0.243 | 0.163 | 1.59 (0.98–2.56) | 0.06 | |
| GCGTG | 0.035 | 0.121 | 0.33 (0.15–0.74) | 0.007 | |
| ACGTG | 0.197 | 0.204 | 0.95 (0.60–1.49) | 0.82 | |
| GCGTT | 0.099 | 0.072 | 1.40 (0.76–2.59) | 0.28 | |
| GAGCG | 0.086 | 0.076 | 1.46 (0.84–2.55) | 0.18 | |
| AAGCT | 0.044 | 0.028 | 1.58 (0.66–3.83) | 0.31 | |
| ACATG | 0.011 | 0.019 | 0.55 (0.14–2.15) | 0.39 | |
| ACATT | 0.004 | 0.026 | 0.18 (0.02–1.42) | 0.10 | |