Table 1.
Model parameters for myocytes under normal and different stages of ischemia
| Parameter | Stage of ischemia (min) | ||||
|---|---|---|---|---|---|
| Control | Phase 1a | Phase 1b | |||
| 0 | 5 | 10 | 15 | 30 | |
| Hyperkalemia | |||||
| [K+]e (mmol/l) | 5.4 | 8.9 | 12.5 | 14 | 15.5 |
| Acidosis | |||||
| g Ca (%) | 100 | 87.5 | 75 | 50 | 50 |
| g Na (%) | 100 | 87.5 | 75 | 50 | 50 |
| V s,Na (mV) | 0 | 1.7 | 3.4 | 3.4 | 3.4 |
| I NaCa (%) | 100 | 100 | 100 | 60 | 20 |
| Acidosis and hypoxia | |||||
| [Na+]i (mmol/l) | 14 | 14 | 14 | 17 | 20 |
| I NaK (%) | 100 | 100 | 100 | 65 | 30 |
| g RyR (%) | 100 | 100 | 100 | 50 | 5 |
| νup (%) | 100 | 100 | 100 | 95 | 90 |
| Hypoxia | |||||
| [ATP]i (mmol/l) | 6.8 | 5.7 | 4.6 | 3.5 | 2.0 |
| [ADP]i (μmol/l) | 15 | 57 | 99 | 136 | 164 |