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. 2012 Jan 15;13(2):61–68. doi: 10.4161/cbt.13.2.18872

Figure 3.

Figure 3

Key proteins involved in homologous recombination (HR). The main engine of HR is Rad51, which catalyzes the key reactions of synapsis-homology search and DNA strand invasion. Altogether, there are more than 200 proteins involved in different aspects of HR, providing a sufficient number of context-specific factors to explain the extraordinary versatility of HR, i.e., its functions in the repair of double-strand breaks (DSBs), DNA interstrand crosslinks (ICLs), and in resolution of stalled/collapsed replication forks. Any of the proteins are potentially targetable for cancer therapy.