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General health of mice. (A) Comparison of body weight change for ApcMin/+ and AOM mice maintained on a control (solid lines) or calcium (dashed lines) supplemented diets, with or without AG1478. Blood collected at the end of treatment was used for measurement of (B) serum calcium and (C) alanine aminotransferase (ALT) levels. The normal lower and upper levels are indicated for each test. Error bars show SEM.
