Skip to main content
. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: J Am Chem Soc. 2012 Mar 9;134(11):5157–5164. doi: 10.1021/ja210399h

Figure 4.

Figure 4

Effect of the 15-nt hairpin complement (HP compl) on the hTERT 5-12 fragment. (a) DMS footprinting of the hTERT fragment without (lane 2) and with (lane 3) HP compl shows that the complement has no effect on the footprinting pattern. Circles to the right of the gel indicate protection (open circles) and cleavage (filled circles) by DMS. Vertical black lines to the left indicate G-tracts. (b) Major transitions (>25% probability) of the hTERT fragment in the presence of the HP compl (unfolding events are shown with black solid arrows; refolding events are shown with red dotted arrows).