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. 2012 Mar 15;125(6):1556–1567. doi: 10.1242/jcs.095729

Fig. 3.

Fig. 3.

The lipid phosphatase activity of PTEN mediates the regulation of TDP-43 by PTEN. (A) Transfection of C124A induces increased expression of TDP-43 in cultured cortical neurons (n=4 for each group; *P<0.05 vs GFP). (B) Transfection of G129E increases TDP-43 expression in cultured cortical neurons (n=4 for each group; *P<0.05 vs GFP). (C) The level of TDP-43 is decreased in control neurons at 6 hours after cycloheximide treatment in cultured cortical neurons (n=6 for each group; *P<0.05 vs 0 h). (D) The protein level of TDP-43 is not altered following treatment for 12 hours with cycloheximide in THA-treated neurons. (E) The protein level of TDP-43 remains unchanged following treatment with cycloheximide for 12 hours in bpV(pic)-treated neurons. All bar graphs show means ± s.e.m.