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. 2012 Mar 15;125(6):1556–1567. doi: 10.1242/jcs.095729

Fig. 6.

Fig. 6.

Suppressing nuclear TDP-43 increases the death of cortical neurons at early stages after THA treatment. (A) Sample images (left) and summarized data (right) indicate that TDP-43 siRNA (siRNAtdp43) but not the non-targeting control siRNA (NsiRNA) inhibits TDP-43 expression in the nucleus of normal cortical neurons (means ± s.e.m.; for each group, n=35 cells from three independent experiments; *P<0.05 vs NsiRNAtdp43; data are normalized to NsiRNA). (B) Representative images (left) and summarized data (right) show that knockdown of TDP-43 with siRNAtdp43 promotes cortical neuronal death at 3 days after 100 μM THA treatment compared with the control neurons transfected with NsiRNA (means ± s.e.m.; for each group, n=50 cells from three independent experiments; *P<0.05 vs GFP; data are normalized to GFP). The neurons were transfected with siRNAs at 1 day after THA treatment.