Table 1.
Ion channels associated with multi-PDZ domain proteins
| Ion channel | Scaffold protein (number of PDZ domains) | Reference |
|---|---|---|
| NMDA receptors | PSD-95 (3) | (20) |
| SAP-102 (3) | (21) | |
| AMPA receptors | GRIP1 (7) | (22) |
| PICK-1 (1*) | (23) | |
| SAP97 (3) | (24) | |
| Shaker K+ channels | PSD-95 (3) | (25) |
| Dlg-1 (3) | (26) | |
| TRP | INAD (5) | (27) |
| Ca2+ channels | Mint-1 (2) | (28) |
| CFTR | CAP70 (4) | (5) |
| NHERF (2) | (6) | |
| Kir4.1 K+ channels | CIPP1 (4) | (29) |
| ENaC | PICK1 (1*) | † |
NMDA, N-methyl-d-aspartate; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. TRP, transient receptor potential.
*
PICK1 protein forms oligomers via PICK1–PICK1 interactions (23).
†
Hruska-Hageman, A. M., Price, M. P., Johnson, W. A. & Welsh, M. J. (2000) J. Neurosci. 26, 1906 (abst.).