Skip to main content
. 2012 Apr 11;32(15):5054–5061. doi: 10.1523/JNEUROSCI.4951-11.2012

Figure 3.

Figure 3.

Overexpression of mouse NMNAT protects axons and dendrites from taxol-induced degeneration. A–D, Confocal images of single representative nerves labeled with ppkEGFP. Genotypes are elavgal4, ppkEGFP/+ (Ctrl, A and C), or UAS-cytNMNAT1/+;elavgal4, ppkEGFP/+ (NMNAT, B and D). Animals were treated with DMSO (A, B) or taxol (C, D) for 4 d and then analyzed. Scale bar (A), 2 μm. E, Quantification of GFP-labeled axons per nerve following taxol treatment in the genotypes shown in A–D. N = 10, 17, 17, and 22 for the genotypes quantified. **p < 0.01. F, G, Dendrites and cell bodies of ddaC neurons treated with taxol from control (same genotype as A and C) and UAS-cytNMNAT1-expressing (same genotype as B and D) animals. Scale bar (F), 10 μm.