Figure 4.

Wallenda is required for taxol-induced axonal degeneration in Drosophila. A–D, Confocal images of single representative nerves labeled with ppkEGFP. Animals were treated with DMSO (A, C) or taxol (B, D) for 4 d and then analyzed. WT genotype is heterozygous wnd³/+; wnd genotype is wnd³/wnd². A, Wild-type vehicle; B, wnd mutant vehicle; C, wild-type taxol; D, wnd mutant taxol. Scale bar (A), 2 μm. E, Quantification of axonal preservation in the genotypes shown in A–D. N = 54, 54, 58, and 77 for genotypes quantified. **p < 0.01.