TABLE 2.

Pharmacokinetic parameters for total radioactivity in plasma after oral and intravenous administration of [³⁵S]2

Data are presented as mean ± S.D. values derived at each time point from nine male and nine female rats.

Parameter	Intravenous Dose		Oral Dose
	Male	Female	Male	Female
t1/2, h	7.8	9.0	NC	NC
Tmax, h	NA	NA	4	4
Cmax, μg-Eq/ml	6.51 ± 0.60	4.49 ± 0.16	2.53 ± 0.30	2.50 ± 0.22
Cmaxp.o./Cmaxi.v.	NA	NA	0.39	0.56
AUC, h-μg-Eq/ml	53.58 ± 1.37	35.21 ± 3.23	26.86 ± 3.52	27.37 ± 2.52
AUCp.o./AUCi.v.	NA	NA	0.50	0.78

NC, not calculated; NA, not applicable; AUC_p.o., area under the plasma concentration-time profile with oral dose administration; AUC_i.v., area under the plasma concentration-time profile with intravenous dose administration.