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The location of Gln273 in the CYP3A4 crystal structure. A, ribbon diagram showing the spatial relationships between Gln273 and the C-, E-, F-, G-, H-, and I-helices. B, Gln273 and Asp277 are within hydrogen bonding distance from each other (2.4 Å). This interaction may be disrupted by covalent adduction of Gln273 by the reactive intermediate (epoxide of DHBG). C, Gln273 is partially shielded from the solvent by His267 and Asp277.
