TABLE 2.

The observed ER_α, permeability parameters (PS_PC) of mannitol and permeability parameters (PS_obs and PS_D) of PAN isomers transport in empty and ABCG2-MDCKII as a function of PAN donor concentration

PS units are expressed as (μl/h)/cm².

Cell Line	Substrate/Isomer	Parameter	3 μM	10 μM	30 μM	50 μM	200 μM	Mean	S.D.
Empty-MDCKII	(−)PAN	PSobs A→B	126	143	140	137	152	140	9
		PSobs B→A	128	155	150	146	151	146	11
		ERα	1.01	1.08	1.08	1.06	0.99	1.04	0.04
	(+)PAN	PSobs A→B	140	140	137	136	159	142	10
		PSobs B→A	149	157	156	149	166	155	7
		ERα	1.06	1.13	1.14	1.09	1.04	1.09	0.04
	(−)/(+)PAN	PSD	267	291	289	277	309	287	16
	Mannitol	PSpc	2.3	3.29	1.22	3.44	2.29	2.51	0.9
rAbcg2-MDCKII	(−)PAN	PSobs A→B	16.9	31.6	67.6	109	132	N.A.	N.A.
		PSobs B→A	254	255	211	156	132	N.A.	N.A.
		ERα	15	8.06	3.12	1.44	1	N.A.	N.A.
	(+)PAN	PSobs A→B	30	42.2	43.6	79.6	126	N.A.	N.A.
		PSobs B→A	258	246	240	195	179	N.A.	N.A.
		ERα	8.61	5.81	5.5	2.45	1.42	N.A.	N.A.
	Mannitol	PSPC	1	1.03	0.76	0.78	0.71	0.86	0.15

N.A., not applicable.