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Effects of pVNTR-S, pVNTR-M, and pVNTR-L alleles on constitutive CYP2C9 promoter activity. HepG2 cells were transfected with reporter gene constructs containing pVNTR-M, pVNTR-M, or pVNTR-S in combination with other SNPs/haplotypes in naturally occurring combinations, as shown in Table 3. Luciferase activities were measured 48 h after transfection. Data are mean ± S.D., n = 3. Compared with reference construct M1; *, P < 0.05 (analysis of variance with Dunnett's post hoc test).
