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Relative effects of TM5 serine to alanine mutations on binding affinity of cyclohexyl-substituted bicyclic compounds. Data represent ΔpKi values (mean and S.E.M.) for each mutant relative to that for the wild type of the cyclohexyl-substituted isochroman (□), carbocyclic (▩), and chroman (■) (n = 4 matched experiments). *, p < 0.05; **, p < 0.01, significantly different from cyclohexyl chroman (one-way ANOVA with Dunnett's post-test).
