Skip to main content
. 2012 May;341(2):455–463. doi: 10.1124/jpet.111.190595

Fig. 3.

Fig. 3.

Acquisition, but not expression, of EtOH (E)-induced behavioral sensitization is prevented by the CORT synthesis inhibitor metyrapone. A, results for the acquisition study. Shown is total distance traveled (cm; mean ± S.E.M.) after 1.5 g/kg EtOH treatment in D2 mice (n = 12–14 per group), treated for 10 days with metyrapone (0, 25, or 50 mg/kg), then saline (S) or 1.5 g/kg EtOH, with a 30-min separation between treatments. ***, p < 0.001 for the comparison with the respective repeated saline-treated group. †, p < 0.05 and ††, p < 0.01 for the comparison with the 0 metyrapone-EtOH group. B, results for the expression study. Shown is total distance traveled (cm; mean ± S.E.M.) in D2 mice (n = 12 per group) treated with 0, 25, or 50 mg/kg metyrapone, and then saline or EtOH (1.5 g/kg) 30 min later. During days 1 to 10, mice were treated with saline or EtOH (1.5 g/kg) without metyrapone pretreatment. ###, p < 0.01 for the main effect of repeated EtOH exposure (sensitization).