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. 2012 May;341(2):455–463. doi: 10.1124/jpet.111.190595

Fig. 5.

Fig. 5.

Repeated CORT injections induce a sensitized response to the locomotor-stimulating effects of EtOH (E). A, total distance traveled (cm; mean ± S.E.M.) after treatment with saline (S) or 1.5 g/kg EtOH in D2 mice (n = 13–14 per group) that were pretreated on 10 days with CORT (0, 10, or 20 mg/kg). **, p < 0.01 and ***, p < 0.001 for the comparison with the respective saline-treated group. †, p < 0.05 for the comparison with the 0 mg/kg CORT-EtOH group. B, plasma CORT levels (μg/dl; mean ± S.E.M.) obtained on days 1 and 10 of CORT administration (different animals than those shown in A; n = 10 per group). Blood samples were collected from separate groups of animals at 1, 2, 4, or 24 h after CORT administration, but the same animals contributed samples on both days 1 and 10. **, p < 0.01 and ***, p < 0.001 for the comparison with the respective saline-treated control on the same day and at the same time.