Fig. 5.

Complementary face mutations alter the rate of [³H]granisetron dissociation in the presence of VUF10166. W90C, Q92C, and Y153C substitutions in the complementary face of the 5-HT₃B subunit produce mutant heteromeric receptors with rates of dissociation that resemble those found in homomeric receptors (Fig. 2D). In contrast, K181C in the principal face produced receptors with dissociation rates similar to those of the wild-type heteromer. Values are the mean ± S.E.M. Sample size and rate constants for these curves can be found in the text.