TABLE 2.
5-HT agonist parameters before and after MTSEA treatment
Data are means ± S.E.M. No data were significantly different before and after MTSEA (p > 0.05).
| Mutant | pEC50 | EC50 | nH | n |
|---|---|---|---|---|
| μM | ||||
| Before MTSEA | ||||
| Wild type | ||||
| AB | 4.56 ± 0.03 | 27.6 | 1.05 ± 0.09 | 12 |
| B loop | ||||
| ABK181C | 4.43 ± 0.09 | 36.8 | 0.82 ± 0.11 | 8 |
| ABI183C | 4.63 ± 0.09 | 23.4 | 0.83 ± 0.16 | 3 |
| D loop | ||||
| ABQ92C | 4.77 ± 0.08 | 16.9 | 1.03 ± 0.20 | 4 |
| ABW90C | 5.07 ± 0.07 | 8.43 | 1.06 ± 0.16 | 5 |
| After MTSEA | ||||
| Wild type | ||||
| AB | 4.68 ± 0.04 | 20.9 | 1.06 ± 0.13 | 4 |
| B loop | ||||
| ABK181C | 4.51 ± 0.12 | 30.7 | 0.76 ± 0.19 | 4 |
| ABI183C | 4.79 ± 0.07 | 16.3 | 1.26 ± 0.24 | 3 |
| D loop | ||||
| ABQ92C | 4.69 ± 0.12 | 20.3 | 0.70 ± 0.15 | 3 |
| ABW90C | 5.13 ± 0.08 | 7.42 | 1.16 ± 0.29 | 3 |