TABLE 3.
mRNA levels of proinflammatory mediators in HIF-1βLysMCre− and HIF-1βLysMCre+ mice after BDL
HIF-1βLysMCre− and HIF-1βLysMCre+ mice were subjected to sham operation or BDL. Ten days after surgery, mRNA levels were quantified by real-time PCR. Data are expressed as mean ± SEM; n = 8.
Gene Name/Function | Sham Operation |
BDL |
||
---|---|---|---|---|
HIF-1βLysMCre− | HIF-1βLysMCre+ | HIF-1βLysMCre− | HIF-1βLysMCre+ | |
KC | 1.0 ± 0.2 | 2.4 ± 1.0 | 8.3 ± 1.9a | 8.2 ± 0.8a |
MIP-2 | 1.0 ± 0.3 | 2.9 ± 1.1 | 14.2 ± 0.3a | 20.6 ± 0.3a |
TNF-α | 1.2 ± 0.6 | 1.2 ± 0.4 | 4.7 ± 1.0a | 3.4 ± 0.7a |
Significantly different (p < 0.05) from sham-operated mice.