TABLE 4.
mRNA levels of profibrotic and proangiogenic mediators in HIF-1βLysMCre− and HIF-1βLysMCre+ mice after BDL
HIF-1βLysMCre− and HIF-1βLysMCre+ mice were subjected to sham operation or BDL. Ten days after surgery, mRNA levels were quantified by real-time PCR. Data are expressed as mean ± SEM; n = 8.
| Gene Name/Function | Sham Operation |
BDL |
||
|---|---|---|---|---|
| HIF-1βLysMCre− | HIF-1βLysMCre+ | HIF-1βLysMCre− | HIF-1βLysMCre+ | |
| PAI-1 | 1.5 ± 1.0 | 1.5 ± 1.0 | 148.1 ± 56.0a | 174.4 ± 43.9a |
| FGF-2 | 1.0 ± 0.1 | 0.7 ± 0.1 | 3.7 ± 1.6a | 1.5 ± 0.3 |
| PDGF-B | 1.0 ± 0.1 | 1.0 ± 0.8 | 14.5 ± 0.3a | 4.7 ± 0.4a,b |
| MCP-1 | 1.0 ± 1.3 | 1.0 ± 1.7 | 12.3 ± 0.3a | 3.8 ± 0.6a,b |
| VEGF-A | 1.0 ± 0.1 | 0.7 ± 0.05a | 0.4 ± 0.01a | 0.4 ± 0.02a |
| Ang-1 | 1.0 ± 0.1 | 1.9 ± 1.1 | 1.0 ± 0.1 | 1.0 ± 0.1 |
| Ang-2 | 1.0 ± 0.2 | 0.7 ± 0.2 | 1.6 ± 0.4 | 1.4 ± 0.3 |
a
Significantly different (p < 0.05) from sham-operated mice.
b
Significantly different (p < 0.05) from BDL HIF-1βLysMCre− mice.