Fig. 2.

Modulation of the behavioral stimulant effects of cocaine after pretreatment with Ro 60-0175 alone and in combination with SB 242084 in squirrel monkeys (n = 4) trained to lever-press on a fixed-interval 300-s schedule of stimulus termination. A, effects of pretreatment with Ro 60-0175 (veh, 0.1–0.3 mg/kg) before administration of saline or multiple doses of cocaine. B, effects of pretreatment with SB 242084 (veh, 0.01–0.3 mg/kg) on the Ro 60-0175-induced attenuation of behavioral-stimulant effects induced by the maximally effective dose of cocaine (coc). Otherwise, as in Fig. 1.