Figure 5.

Strategies to overcome resistance in hormone receptor–positive breast cancer.

Abbreviations: CBP, CREB-binding protein; ER, estrogen receptor; ERE, estrogen response element; HER-2, human epidermal growth factor receptor 2; IGF-1R, insulin-like growth factor 1 receptor; MAPK, mitogen-activated protein kinase; MEK, MAPK/extracellular signal–related kinase kinase; mTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol 3-kinase; PR, progesterone receptor; SOS, son of sevenless.

Nat Rev Clin Oncol 2010;7:139–147, with permission from Nature Publishing Group.