Fig. 4.

Effects of interleukin-1 receptor antagonist (IL-1ra), fluoxetine (FLX), and their combination on the evoked 5-HT release from the cortex. (a) Sample voltagrams show the reduced 5-HT release in control (i.e., post-status epilepticus [SE], vehicle treated) as compared with naïve rats; the lack of effects of fluoxetine in post-SE rats; the increased 5-HT release upon the IL1-ra administration; and the increase of 5-HT release greater than normal level after the combined IL-1ra/FLX treatment (compare with naïve animals). Inset shows the ramp current applied to dorsal raphe to evoke 5-HT release from the cortex. (b) Statistical analysis of the fast cyclic voltammetry assay. Each group included 6 rats. Data are shown as mean ± SEM. *p < 0.05 versus naïve; ^†p versus SE alone; ^‡p versus IL-1ra alone and versus FLX alone (one-way analysis of variance + Neuman-Keuls post hoc test)