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Early nonmotor deficits in Thy1-aSyn (black) versus wild-type (grey). Cognitive deficits in (A) One-trial object-place recognition test at 4 to 5 months (mean + SEM; n = 10-12; *p < 0.05 compared to wild-type; Student’s t test), (B) Y-maze at 7 to 9 months (mean + SEM; **p < 0.01; n = 10-12; Student’s t test), and (C) novel object recognition test at 4 to 5 months (mean + SEM; n = 17-18; *p < 0.01 Student’s t test).
