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Brain sections (1 hemisphere) show increased immunostaining for mouse/human aSyn (mouse anti-alpha-synuclein); clone 42, 1:500 (BD Biosciences, San Jose, CA) (A) in Thy1-aSyn mice (5 months old) compared to wild-type (WT) littermates. (B) 3.4-fold increase in aSyn in the SN pars compacta of Thy1-aSyn mice (SNc; arrows in [A]) (Image J, mean + SEM; n = 5; **p < 0.01 Student’s t test)
