Fig. 7.

Parkinsonism-like phenotype in Thy1-aSyn mice aged 14 months. (A) Thy1-aSyn mice show a 40% loss of dopamine in the striatum compared to age matched wild-type (WT) mice (mean ± SEM; n = 8; *p < 0.05; Student’s t test). (B) Thy1-aSyn mice need longer to remove a sticker from their nose compared to wild-type. This behavioral deficit can be reversed by L-dopa (mean ± SEM; n = 6-7; **p < 0.01 compared to wild-type vehicle, Mann-Whitney U test). (See Lam, et al., 2011 [24] for details)