Table 1.
Alpha-Synuclein Over-Expression in Brain Regions of Thy1-aSyn Mice Assessed with Immunohistochemistry
| Brain Regions | Wild-Type | Thy1-aSyn | ||
|---|---|---|---|---|
| Substantia nigra pars reticulata | 13,821 | ± 2466 | 20858 | ± 2621 |
| Substantia nigra pars compacta | 5175 | ± 611 | 17,536* | ± 761 |
| Thalamus | 4465 | ± 457 | 28,209* | ± 616 |
| Dentate gyrus | 19,975 | ± 1252 | 39,856* | ± 2305 |
| Hippocampus CA1 | 18,361 | ± 1540 | 43,918* | ± 1529 |
| Hippocampus CA2 | 22,786 | ± 1722 | 40,252* | ± 2027 |
| Hippocampus CA3 | 23,949 | ± 1979 | 43,739* | ± 2301 |
| anterior olfactory nucleus | 21,067 | ± 2336 | 41,296* | ± 2986 |
| Olfactory bulb, granule cell layer | 17,675 | ± 1870 | 26,421* | ± 2167 |
| Orbital/association cortex | 17,448 | ± 2215 | 43,714* | ± 2679 |
| Motor cortex | 12,472 | ± 746 | 38,101* | ± 2816 |
| Sensory cortex | 12,249 | ± 1008 | 32,126* | ± 1726 |
| Striatum | 14,285 | ± 1232 | 21,692 | ± 1510 |
Anti-alpha-synuclein antibody that recognizes both mouse and human alpha-synuclein, mouse anti-alpha-synuclein; clone 42, 1:500 (BD Biosciences, San Jose, CA); immunofluorescence intensity units, mean ± SEM; *p < 0.05