Table 1.
Summary of the Animal Models of Insult in the Immature Brain to Induce Epileptogenesis
| How model is created | Age | Cell-injury after the injury in the immature brain | Epileptogenesis/Spontaneous recurrent seizure | |
|---|---|---|---|---|
| Lithium-pilocarpine status epilepticus | LiCl followed by pilocarpine | P14-adulthood | P7: Very little | No |
| P14: CA1 | Yes in 10-20 % | |||
| P21: Hilus-CA3 | Yes in almost 100 % | |||
| Hyperthermic seizure | heated airstream | P10-P11 | No | Yes |
| 35 % after 26 min HS | ||||
| 45 % after 64 min HS | ||||
| Hypoxia | Unilateral carotid ligation | P7 | Yes | Yes 56 % |
| 100 % when cerebral infarcts | ||||
| 0 % in absence of brain injury | ||||
| Hypoxia | Global hypoxia for 15 min using an airtight chamber | P10 | No | Yes |