Table 3.

Values of the predicted coated area and the scoring function (the “score” ) for the set of test gels: undiluted, after dilution by 20% with vaginal fluid simulant, and the average of those two values [10]

Undiluted gel			Diluted gel			Average of undiluted and diluted scores
Gel	Area at 2 h (cm2)	Score	Gel	Area at 2 h (cm2)	Score	Gel	Score
KY Jelly	98.43	0.9688	Replens	101.83	0.9756	1% TFV	0.8971
1% TFV	98.31	0.9664	HEC placebo gel	110.09	0.8655	HEC placebo gel	0.8467
Carraguard	105.03	0.9329	1% TFV	112.92	0.8277	Carraguard	0.7535
HEC placebo gel	90.99	0.8279	Gynol II	83.36	0.6949	Replens	0.6895
Gynol II	72.71	0.5287	Carraguard	131.94	0.5741	KY Jelly	0.6418
Replens	63.51	0.4033	RepHresh	72.58	0.5268	Gynol II	0.6118
UC781 clinical	53.57	0.287	KY Jelly	151.39	0.3148	RepHresh	0.3281
RepHresh	35.98	0.1294	UC781 clinical	260.95	0	UC781 clinical	0.1435

The computations are based upon a 3.5-mL gel volume, and an upper bound on gel leakage V_L =1.5 mL. Coated area is computed at 2 h after the onset of gel spreading