Table 3. Effect sizes for comparisons between no disorder (ND) vs major depressive disorder (MDD; all), and MDD-only vs MDD with comorbid anxiety disorder.
| Groups | N | Effect size | Groups | N | Effect size | |
|---|---|---|---|---|---|---|
| Genetic model genes | ||||||
| ATP11C | ND | 14 | −0.84 | MDD only | 5 | 0.49 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| CD59 | ND | 14 | −0.78 | MDD only | 5 | 0.94 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| FAM46A | ND | 14 | −0.00 | MDD only | 5 | −0.78 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| IGSF4A/CADM1 | ND | 14 | −0.59 | MDD only | 5 | 0.95 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| MAF | ND | 14 | −0.62 | MDD only | 5 | −0.10 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| MARKS | ND | 14 | −0.40 | MDD only | 5 | −0.37 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| NAGA | ND | 14 | −0.29 | MDD only | 5 | −0.94 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| RAPH1 | ND | 14 | −0.63 | MDD only | 5 | 0.25 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| TLR7 | ND | 14 | −0.00 | MDD only | 5 | −0.93 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| UBE3A | ND | 14 | −0.27 | MDD only | 5 | 0.41 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| ZNF291/SCAPER | ND | 14 | −0.36 | MDD only | 5 | −0.82 |
| MDD only | 14 | MDD + anxiety disorder | 9 | |||
| Chronic stress model genes | ||||||
| AHSP | ND | 14 | −0.46 | MDD only | 5 | −0.59 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| AMFR | ND | 14 | −0.57 | MDD only | 5 | −1.06 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| CAT | ND | 14 | −0.54 | MDD only | 5 | −0.55 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| CDR2 | ND | 14 | −0.87 | MDD only | 5 | 0.99 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| CMAS | ND | 14 | −0.77 | MDD only | 5 | 0.85 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| DGKA | ND | 14 | −0.07 | MDD only | 5 | −1.47 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| EMB | ND | 14 | −0.19 | MDD only | 5 | 0.36 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| FECH | ND | 14 | −0.41 | MDD only | 5 | −0.08 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| GCLM | ND | 14 | −0.19 | MDD only | 5 | 0.69 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| GGA3 | ND | 14 | −0.25 | MDD only | 5 | −0.58 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| IRF3 | ND | 14 | −0.34 | MDD only | 5 | −0.86 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
| KIAA1539 | ND | 14 | −0.01 | MDD only | 5 | −0.99 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| PSME1 | ND | 14 | −0.52 | MDD only | 5 | 0.52 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| PTP4A3 | ND | 14 | −0.77 | MDD only | 5 | 0.45 |
| MDD | 13 | MDD + anxiety disorder | 8 | |||
| SLC4A1 | ND | 14 | −0.07 | MDD only | 5 | −0.88 |
| MDD | 14 | MDD + anxiety disorder | 9 | |||
Positive effect size indicates increased fold change compared with ND or MDD-only, whereas negative is the opposite.