Table 2. Relationship between maternally derived deletions in the 22q11DS subjects and neuropsychological performance (data available for 19 subjects with maternally derived deletions).
| Test | DGCR6 | DGCR6L |
|---|---|---|
| IQ (WISC)—verbal comprehension | −0.191 | −0.236 |
| IQ—perceptual organization | −0.120 | −0.185 |
| IQ—working memory | 0.170 | 0.171 |
| IQ—processing speed | −0.184 | −0.228 |
| Executive function (WCST)—PE | 0.183 | 0.251 |
| Sustained attention—CPT AX | −0.337 | −0.331 |
| Sustained attention—CPT IP | −0.380 | −0.332 |
| Parent CBCL internalizing T-score | −0.441 | −0.461 |
| Anxiety disorders | F=7.8* | F=5.37* |
*P<0.05.
**P<0.01.
Moderate and large effect sizes are in bold (small=0.1, medium=0.3 and large=0.5 for Pearson's correlations and small=0.10, medium=0.25 and large=0.40 for ANOVA).
Pearson's correlations were computed for all variables, except for anxiety disorders, wherein ANOVA was computed, to examine differences in expression of DGCR6 and DGCR6L in those with and without an anxiety disorder.