Table 1. Structural homologs and conserved domains of the Gin, VapD, HicA, YafO and RnlA toxin super-families.
| Super-family | Structural homologs | Conserved domains | References |
|---|---|---|---|
| Type II |
|
|
|
| GinA |
None |
Siphovirus Gp157 protein family. Related to SFi phage from Streptococcus thermophilus. Thought to protect against phages |
1, 32 |
| GinB |
RelE toxin of Thermus thermophilus (PDB: 2khe) |
DUF213, COG4680: uncharacterized protein conserved in bacteria |
1, 43 |
| GinC |
Protein of unknown function of Bacillus halodurans UPF0223 (PDB: 2oy9) |
UPF0223, PRK04387: uncharacterized protein family |
1 |
| GinD |
None |
None |
1 |
| VapD |
Sequence specific endoribonuclease associated with CRISPR in Sulfolobus solfataricus (PDB: 3exc) |
Cas2 protein associated with CRISPR; RNase specific to U-rich region |
31 |
| HicA |
Protein of unknown function of Thermus thermophilus (PDB: 1whz) Endonuclease of Pyrococcus furiosus (PDB: 1dq3) |
YcfA super-family: hypothetical proteins of unknown function; COG1724: predicted RNA binding proteins (dsRBD-like fold), HicA family |
1, 20 |
| YafO |
None |
None |
44, 45 |
| RnlA |
None |
None |
46 |
| Solitary |
|
|
|
| GinE |
Putative RNA binding protein in Lactobacillus plantarum (PDB: 3kwr) |
UPF0150: protein family that may be involved in RNA metabolism, including RNA binding and cleavage |
1 |
| GinF |
Pleckstrin domain of Shewanella loihica (PDB: 3dcx) |
None |
1, 33 |
| GinG |
None |
None |
1 |
| GinH |
None |
None |
1 |
| GinI | Protein of unknown function of Thermus thermophilus (PDB: 1whz) Endonuclease of Pyrococcus furiosus (PDB: 1dq3) |
YcfA super-family: hypothetical proteins of unknown function; COG1724: predicted RNA binding proteins (dsRBD-like fold), HicA family | 1, 20 |