Table 1. Case-control Analyses Within-Whites for 10 OXTR SNPs (showing count and (%)).
Section 1. A: Adolescent Patients with Conduct Disorder (at least 3 lifetime DSM-IIIR conduct disorder criteria) vs. Adolescent Controls without Conduct Disorder. Section 1. B: Parents of adolescent patients vs. parents of adolescent Controls.
| Section 1. A – Patient (Pt) vs. Control (Ct) | Section 1. B – Pt parent vs. Ct Parent | |||||||
|---|---|---|---|---|---|---|---|---|
| rs237884 | GG | AG | AA | P-value | GG | AG | AA | P-value |
| Ct | 10 (10.6) | 33 (35.1) | 51 (54.3) | 0.51 | 11 (6.6) | 66 (39.8) | 89 (53.6) | 0.71 |
| Pt | 12 (6.7) | 68 (38.0) | 99 (55.3) | 20 (8.9) | 86 (38.4) | 118 (52.7) | ||
| rs1042778 | TT | GT | GG | P-value | TT | GT | GG | P-value |
| Ct | 12 (13.6) | 46 (52.3) | 30 (34.1) | 0.17 | 21 (13.4) | 75 (47.8) | 61 (38.9) | 0.81 |
| Pt | 31 (18.0) | 69 (40.1) | 72 (41.9) | 35 (15.7) | 102 (45.7) | 86 (38.6) | ||
| rs2139184 | CC | AC | AA | P-value | CC | AC | AA | P-value |
| Ct | 93 (100) | 0 (0) | 0 (0) | 0.18a | 163 (98.2) | 3 (1.8) | 0 (0) | 0.99a |
| Pt | 180 (96.8) | 6 (3.2) | 0 (0.0) | 233 (97.5) | 6 (2.5) | 0 (0) | ||
| rs237885 | TT | GT | GG | P-value | TT | GT | GG | P-value |
| Ct | 20 (22.2) | 47 (52.2) | 23 (25.6) | 0.39 | 37 (24.2) | 84 (54.9) | 32 (20.9) | 0.10 |
| Pt | 36 (20.6) | 80 (45.7) | 59 (33.7) | 40 (18.1) | 115 (52.0) | 66 (29.9) | ||
| rs11706648 | CC | AC | AA | P-value | CC | AC | AA | P-value |
| Ct | 10 (12.2) | 32 (39.0) | 40 (48.8) | 0.74 | 21 (14.2) | 59 (39.9) | 68 (45.9) | 0.93 |
| Pt | 21 (12.9) | 71 (43.6) | 71 (43.6) | 27 (13.8) | 82 (41.8) | 87 (44.4) | ||
| rs237887 | GG | AG | AA | P-value | GG | AG | AA | P-value |
| Ct | 18 (20.9) | 42 (48.8) | 26 (30.2) | 0.22 | 35 (23.0) | 71 (46.7) | 46 (30.3) | 0.37 |
| Pt | 31 (18.6) | 67 (40.1) | 69 (41.3) | 39 (17.8) | 102 (46.6) | 78 (35.6) | ||
| rs4686301 | TT | CT | CC | P-value | TT | CT | CC | P-value |
| Ct | 10 (11.0) | 39 (42.9) | 42 (46.2) | 0.98 | 17 (10.6) | 68 (42.2) | 76 (47.2) | 0.95 |
| Pt | 20 (11.5) | 76 (43.7) | 78 (44.8) | 24 (11.4) | 86 (40.8) | 101 (47.9) | ||
| rs2268491 | TT | CT | CC | P-value | TT | CT | CC | P-value |
| Ct | 4 (4.5) | 19 (21.6) | 65 (73.9) | 0.51 | 2 (1.2) | 33 (20.5) | 126 (78.3) | 0.45 |
| Pt | 4 (2.3) | 34 (19.2) | 139 (78.5) | 6 (2.7) | 38 (17.0) | 179 (80.3) | ||
| rs2268492 | TT | CT | CC | P-value | TT | CT | CC | P-value |
| Ct | 7 (8.1) | 27 (31.4) | 52 (60.5) | 0.05* | 11 (7.0) | 73 (46.2) | 74 (46.8) | 0.49 |
| Pt | 15 (8.7) | 80 (46.5) | 77 (44.8) | 13 (6.2) | 86 (40.8) | 112 (53.1) | ||
| rs237889 | TT | CT | CC | P-value | TT | CT | CC | P-value |
| Ct | 12 (14.5) | 38 (45.8) | 33 (39.8) | 0.25 | 22 (15.1) | 75 (51.4) | 49(33.6) | 0.004** |
| Pt | 23 (14.7) | 55 (35.3) | 78 (50.0) | 41 (21.8) | 63 (33.5) | 84 (44.7) | ||
a
Fisher’s Exact Test;
*
p < 0.05;
**
p <0.01.