Figure 6. The putative “PIKK regulatory complex.” Three common PIKK regulators, the RUVBL1/2 complex, Hsp90 and the Tel2 complex interact with one another. Other factors (RPAP3, NOP17, RPB5, URI and Monad) are shared interactors of the RUVBL1/2 complex, Hsp90 and the Tel2 complex. They are possible PIKK regulators (see Table 1). The interaction between the RUVBL1/2-URI-prefoldin complex and the Tel2 complex is mediated by NOP17 in a Tel2 phosphorylation dependent manner.¹⁶⁶