Table 1.

Results of method validation for monacolin K (lovastatin) using ¹H NMR

Parameter	Result
Investigated linear working range	5 - 100 mg/L
Limit of detectiona	6 mg/L (0.33 mg/capsulec)
Limit of quantitationa	13 mg/L (0.72 mg/capsulec)
Intraday precisionb
Authentic sampled	10%
Standard solution	7.3%
Interday precisionb
Authentic sampled	11%
Standard solution	8.2%
Recovery	104% (at 50 mg/L) 113% (at 20 mg/L)

^a Limit of detection (LOD) and quantitation were determined by establishing a separate calibration curve near LOD. The limits were calculated from the residual standard deviation of the regression line [42]

^b Precisions were expressed as relative standard deviation (%), intraday (n = 5), interday (n = 10)

^c Based on a sample weight of 0.9 g (2 capsules) in 50 mL ethanol

^d Total statins in authentic samples