Table 1.
BF map and histological parameters (mean ± SEM) for the 2 GBM groups (1 and 2) identified by cluster analysis
| BF Map Parameter | Group 1 | Group 2 | P-value |
|---|---|---|---|
| Baseline CT attenuation (HU) | 32 ± 1.3 | 31 ± 1.3 | NS |
| Mean tumor BF (mL/100 g/min) | 45 ± 3.6 | 23 ± 1.5 | <.0005 |
| Tumor BF standard deviation | 25 ± 1.7 | 18 ± 1.0 | <.005 |
| Partition coefficient (lambda) | 1.0 ± 0.02 | 0.94 ± 0.028 | <.05 |
| Ratio tumor BF : normal BF | 1.3 ± 0.14 | 0.72 ± 0.048 | <.0005 |
| Hyperperfusion fraction | 0.76 ± 0.038 | 0.46 ± 0.039 | <.0005 |
| BF histogram kurtosis | −0.35 ± 0.11 | 1.6 ± 0.44 | <.0005 |
| BF histogram skewness | 0.42 ± 0.10 | 1.3 ± 0.11 | <.0005 |
| Histology parameter | |||
| CD31 positivity (% area) | 3.2 ± 0.42 | 4.7 ± 0.67 | <.05 |
| CD105 positivity (% area) | 3.5 ± 0.38 | 5.3 ± 0.70 | <.05 |
| Necrosis (/20) | 11.7 ± 0.96 | 14.4 ± 0.68 | <.05 |
Abbreviations: HU, Hounsfield units; NS, not significant.
Hyperperfusion fraction = part of tumor with BF > 20 mL/100 g/min.